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KMID : 1134120120150030371
Journal of Breast Cancer
2012 Volume.15 No. 3 p.371 ~ p.372
Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?
Maurizio Bellavia

Giuseppe Damiano
Vincenzo Davide Palumbo
Gabriele Spinelli
Giovanni Tomasello
Antonio Marrazzo
Silvia Ficarella
Antonio Bruno
Antonino Sammartano
Tiziana Fiorentini
Antonio Scio
Carolina Maione
Attilio Ignazio Lo Monte
Abstract
Granulomatous mastitis is a rare benign inflammatory disease of the breast with multiple etiologies such as tuberculosis, sarcoidosis, foreign body reaction, and mycotic and parasitic infections. In contrast, idiopathic granulomatous mastitis (IGM) is characterized by the presence of chronic granulomatous lobulitis in the absence of an obvious etiology. Clinically and radiologically it may mimic breast carcinoma and so awareness of surgeons, pathologists, and radiologists is essential to avoid unnecessary mastectomies. Cases of IGM are reported during antidepressant therapy in patients also showing high levels of prolactinemia. In these cases, we believe that surgical excision must be avoided being replaced with a conservative management of the pathological condition based on a corticosteroid treatment.
KEYWORD
Antidepressant therapy, Hyperprolactinemia, Idiopathic granulomatous mastitis, Selective serotonin reuptake inhibitors
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